Sintesi di peptidi ciclici via «click reaction»
Responsabile scientifico: A.M. Papini

In collaborazione con il Prof. Michael Chorev del Laboratory for Translational Research della Harvard Medical School.

Pubblicazioni recenti su riviste ISI:

S. Cantel, A. Le Chevalier-Isaad, M. Scrima, J.J. Levy, R.D. DiMarchi, P. Rovero, J.A. Halperin, A.M. D'Ursi, A.M. Papini, and M. Chorev.
Synthesis and Conformational Analysis of a Cyclic Peptide Obtained via i-to-i+4 Intramolecular Side-Chain-to-Side-Chain Azide–Alkyne 1,3-Dipolar Cycloaddition.
J. Org. Chem. (2008) 73, 15, 5663-5674.

A. Le Chevalier Isaad, F. Barbetti, P. Rovero, A.M. D’Ursi, M. Chelli, M. Chorev, and A.M. Papini. N(alpha)-Fmoc-Protected omega-Azido and omega-Ynoic-alpha-Amino Acids as Building Blocks for the Synthesis of "Clickable" Peptides. Eur. J. Org. Chem. (2008) 5308-5314.

A. Le Chevalier-Isaad, A.M. Papini, M. Chorev, and P. Rovero. Side chain-to-side chain cyclization by click reaction. Peptide Protocol Paper. J. Pept. Sci. (2009), 15, 451-454.

M. Scrima, A. Le Chevalier-Isaad, P. Rovero, A.M. Papini, M. Chorev, and A.M. D'Ursi. CuI-Catalyzed Azide–Alkyne Intramolecular i-to-(i+4) Side-Chain-to-Side-Chain Cyclization Promotes the Formation of Helix-Like Secondary Structures.Eur. J. Org. Chem. (2010), 446-457.

Altre pubblicazioni recenti:

A. Le Chevalier, N. Lubin-Germain, J. Uziel, M. Chelli, F. Lolli, P. Rovero, A.M. Papini. Sugar building-blocks for solid-phase glycopeptides synthesis. In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 680-681.

A. Le Chevalier Isaad, M. Scrima, S. Cantel, J. Levy, P. Rovero, A.M. D'Ursi, M. Chorev, A.M. Papini. Synthesis of a Series of Cyclic i-to-i+4 Side Chain-to-Side Chain 1,4-Disubstituted [1,2,3]triazolyl-Bridged PTHrP(11-19) Derivatives. In Peptides 2008: The Proceedings of the 30th European Peptide Symposium. H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 200-201. ISBN 978-952-92-5198-8.

M. Scrima, A. Le Chevalier-Isaad, M. Grimaldi, Paolo Rovero, A.M. Papini, M. Chorev, A.M. D'Ursi. Conformational Preferences of Cyclopeptides Formed by i-to-i+4 Side Chain-to-Side Chain Cyclization via 1,4-Disubstituted [1,2,3]Triazolyl Moiety. In Peptides 2008: The Proceedings of the 30th European Peptide Symposium. H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 266-267. ISBN 978-952-92-5198-8.

S. Cantel, J.A. Halperin, M. Chorev, M. Scrima, A.M. D’Ursi, J.J. Levy, R.D. Di Marchi, A. Le Chevalier, P. Rovero, and A.M. Papini. Side chain-to-Side chain Cyclization by Intramolecular Click Reaction - Building Blocks, Solid Phase Synthesis and Conformational Characterization. In: Peptides for Youth: The Proceedings of the 20th American Peptide Symposium S. Del Valle, E. Escher, W.D. Lubell (Eds.), Springer (2009), pp. 175-176. ISBN: 978-0-387-73656-3.

C. Testa, S. Carganico, F. Nuti, M. Scrima, A.M. D’Ursi, M.L. Dirain, N. Lubin Germain, C. Haskell-Luevano, M. Chorev, P. Rovero and A.M. Papini. Stabilization of β Turn Conformation in Melanocortin-Like Peptide by Click Side Chain-To-Side Chain Cyclization. In: Peptides 2010, Proceedings of the 31st European Peptide Symposium. Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 14-15. ISBN 0-9715560-5-9.

M. Scrima, A.M. Papini, M. Chorev, A.M. D’Ursi. Molecular Dynamics Calculation and NMR Conformational Studies of Heterodetic Triazolyl Cyclo-Nonapeptides: A Comparative Study. In: Peptides 2010, Proceedings of the 31st European Peptide Symposium. Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 220-221. ISBN 0-9715560-5-9.

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