Interdepartmental Laboratory of Peptide and Protein Chemistry and Biology
 

Synthesis of new dicarba-analogues of Somatostatin
Principal investigator: M.Ginanneschi

 

Selected ISI pubblications:

A. Carotenuto, D. D’Addona, E. Rivalta, M. Chelli, A.M. Papini, P. Rovero, M. Ginanneschi.
Synthesis of a dicarba-analogue of octreotide keeping the type II’ beta-turn of the pharmacophore in water solution.
Lett. Org. Chem. (2005) 2, 274-279.

D. D’Addona, A. Carotenuto, E. Novellino, V. Piccand, J.C. Reubi, A. Di Cianni, F. Gori, A.M. Papini, and M. Ginanneschi.
Novel sst5-Selective Somatostatin Dicarba-Analogues: Synthesis and Conformation-Affinity Relationships.
J. Med. Chem. (2008) 51, 3, 512-520.

A. Di Cianni, A. Carotenuto, D. Brancaccio, E. Novellino, J.C. Reubi, K. Beetschen, A.M. Papini, M. Ginanneschi. Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors. J. Med. Chem. (2010) 53, 16, 6188-6197.

 

Other recent pubblications:

D. D’Addona, M. Chelli, A.M. Papini, A. Carotenuto, F. Budelli, M. Ginanneschi.
Synthesis of a new dicarba-analogue of the drug octreotide.
In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds), Kenes International, Geneva, Switzerland (2005), pp. 202-203.

D. D'Addona, F. Gori, A. Di Cianni, F. Bucelli, M. Chelli, A.M. Papini, A. Carotenuto, M. Ginanneschi. A new synthetic approach to unsaturated and saturated dicarba-analogues of octreotide. In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 582-583.

A. Di Cianni, D. D’Addona, F. Rizzolo, A.M. Papini, M. Ginanneschi. On-resin microwaves-assisted ring closing metathesis for rapid synthesis of octreotide dicarba-analogues. In Peptides 2008: The Proceedings of the 30th European Peptide Symposium. H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 274-275. ISBN 978-952-92-5198-8.

G. Cane, A. Di Cianni, M. Lumini, AM. Papini, and M. Ginanneschi. An Efficient MW-Assisted Synthesis of Dicarba-Analogues. In: Peptides 2010, Proceedings of the 31st European Peptide Symposium. Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 184-185. ISBN 0-9715560-5-9.

  

 

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