Synthetic strategies

New coupling reagents for automatic, manual and microwave-assisted solid-phase peptide synthesis (SPPS)
Principal investigators: A.M. Papini, G. Sabatino

In cooperation with the group of Prof. Z. Kaminski of the Organic Chemistry Institute of the University of Technology in Łódź (Poland).

Selected ISI publications:

Z.J. Kaminski, B. Kolesinska, J. Kolesinska, G. Sabatino, M. Chelli, P. Rovero, M. Baszczyk, M.L. Gowka, and A.M. Papini.
N-triazinylammonium tetrafluoroborates. A new generation of efficient coupling reagents useful for peptide synthesis.
J. Am. Chem. Soc. (2005), 127, 16912-16920.

K. Jastrząbek, B. Kolesińska, G. Sabatino, F. Rizzolo, A.M. Papini, and Z.J. Kamiński.
Benzyloxy derivatives of triazine-based coupling reagents designed for an efficient solid phase peptide synthesis on polystyrene resin.
Int. J. Pept. Res. Ther. (2007) 13, 1-2, 229-236.

B. Kolesińska, J. Frączyk, G. Sabatino, A.M. Papini, and Z.J. Kamiński.
Sulfonates of N-triazinylammonium salts as highly efficient, inexpensive and environmentally friendly coupling reagents for peptide synthesis.
Chemistry Today (2007) 25, 1, 10-13.

I. Paolini, F. Nuti, M.C. Pozo-Carrero, F. Barbetti, B. Kolesinska, Z.J. Kaminski, M. Chelli, and A.M. Papini.
A convenient microwave-assisted synthesis of N-glycosyl amino acids.
Tetrahedron Letters (2007) 48, 2901-2904.

I. Paolini, F. Rizzolo, and A.M. Papini.
Optimized strategies for the synthesis of biomolecules by the microwave approach.
Chemistry Today (2008) 26, 3, 16-18.

G. Sabatino, A.M. Papini.
Advances in automatic, manual and microwave-assisted solid-phase peptide synthesis
Curr Opin Drug Discov Devel. (2008), 1, 6, 762-770.

F. Rizzolo, C. Testa, D. Lambardi, M. Chorev, M. Chelli, P. Rovero, A.M. Papini. Conventional and microwave-assisted SPPS approach: a comparative synthesis of PTHrP(1–34)NH2. J.Pept. Sci. (2011) 17, 708-714.

A.M. Papini. Peptide chemistry devolution. Chimica Oggi/CHEMISTRY TODAY (2011) 29, 5, 29-30.

Other recent pubblications:

B. Kolesinska, G. Sabatino, J. Kolesinska, M. Chelli, P. Rovero, Z. Kaminski, and A.M. Papini.
ACP solid phase synthesis by new efficient TBCRs.
In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds),Kenes International, Geneva, Switzerland (2005), pp. 232-233.

A.M. Papini, B. Kolesinska, G. Sabatino, J. Kolesinska, and Z. Kaminski.
Triazine-based coupling reagents useful tools for SPPS.
In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds),Kenes International, Geneva, Switzerland (2005), pp. 252-253.

M. de la Cruz Pozo-Carrero, B. Kolesinska, G. Sabatino, M. Chelli, P. Rovero, Z. Kaminski, and A.M. Papini.
An efficient strategy for attachment of Fmoc-amino acids to resins by TBCRs.
In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds),Kenes International, Geneva, Switzerland (2005), pp. 257-258.

G. Sabatino, B. Kolesinska, M. Chelli, P. Rovero, Z. Kaminski, and A.M. Papini.
Automatic SPPS by the new generation of TBCRs.
In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds),Kenes International, Geneva, Switzerland (2005), pp. 263-264.

K. Jastrzabek, B. Kolesinska, M. Blaszczyk, M.L. Glòwka, A.M. Papini, and Z. Kaminski.
2-Chloro-4,6-dibenzyloxy-1,3,5-triazine and N-(4,6-dibenzyloxy-1,3,5-triazinyl-2) ammonium tetrafluoroborates as highly efficient coupling reagents for peptide synthesis in solution.
In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds),Kenes International, Geneva, Switzerland (2005), pp. 335-336.

J. Kolesinska, B. Kolesinska, A.M. Papini, and Z. Kaminski.
Tetrafluoroborates of N-triazinylammonium salts as highly efficient coupling reagents for peptide synthesis in solution.
In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds),Kenes International, Geneva, Switzerland (2005), pp. 337-338.

I. Paolini, F. Nuti, B. Kolesinska, F. Cardona, M. Chelli, A. Brandi, and A.M. Papini.
New glycosylated building-blocks useful for glycopeptide synthesis.
In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds),Kenes International, Geneva, Switzerland (2005), pp. 597-598.

B. Kolesińska, J. Kolesińska, A. Frymarkiewicz, K.K. Wąsikowska, N. Piątkowska, K. G. Jastrząbek, G. Sabatino, F. Rizzolo, A.M. Papini, Z.J. Kamiński.
Synthesis of building blocks for peptide synthesis by using 4-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-4-methyl-morpholinium toluene-4-sulfonate.
In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 518-519.

B. Kolesińska, J. Kolesińska, A. Frymarkiewicz, K.K. Rożniakowski, G. Sabatino, F. Rizzolo, A.M. Papini, Z.J. Kamiński.
Sulfonates of N-triazinylammonium salts as highly efficient, inexpensive and environmentally friendly coupling reagents for peptide synthesis in solution.
In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 604-605.

F. Rizzolo, G. Sabatino, M. Fridkin, M. Chelli, P. Rovero, and A.M. Papini. Microwave-assisted solid-phase peptide synthesis: shifting off the limitations affecting conventional synthetic strategies. In Peptides 2008: The Proceedings of the 30th European Peptide Symposium. H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 156-157. ISBN 978-952-92-5198-8.

F. Nuti, N. Qvit, F. Rizzolo, M. Hurevich, E. Peroni, M. Chelli, P. Rovero, C. Gilon, A.M. Papini. Microwave-Assisted Solid Phase Synthesis of Backbone Cyclic Glycopeptide Libraries. In Peptides 2008: The Proceedings of the 30th European Peptide Symposium. H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 278-279. ISBN 978-952-92-5198-8.

S. Carganico, M.A. Bonache, M.C. Alcaro, M. Chelli, P. Rovero, M. Chorev, A. Lapolla, P. Traldi, and A.M. Papini. Synthetic strategies to Advanced Glycation End products peptides involved in diabetes. In: Peptides for Youth: The Proceedings of the 20th American Peptide Symposium S. Del Valle, E. Escher, W.D. Lubell (Eds.), Springer (2009), pp.  ISBN: 978-0-387-73656-3.

F. Rizzolo, F. Nuti, S. Pandey, M. Chelli, P. Rovero, A.M. Papini. Microwave-Assisted Solid Phase Synthesis of [Asn641(Glc)]FAN(635-655): A New Case Study for Optimisation of Glycopeptide Synthesis. In: Peptides 2010, Proceedings of the 31st European Peptide Symposium. Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 186-187. ISBN 0-9715560-5-9.

F. Rizzolo, C. Testa, M. Chorev, M. Chelli, P. Rovero, A.M. Papini. Conventional and Microwave-Assisted SPPS Approach: A Comparative Study of PTHrP(1-34)NH2 Synthesis. In: Peptides 2010, Proceedings of the 31st European Peptide Symposium. Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 188-189. ISBN 0-9715560-5-9.

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