Personale

Recapiti

Italiano

Curriculum

Pubblicazioni

Insegnamenti

English

Curriculum

Letizia CANU

Ruolo attuale:: Ricercatore Legge 240/10 a tempo determinato
SSD:: MED/13 - Endocrinologia
Afferenza organizzativa:: Dipartimento di Scienze Biomediche, Sperimentali e Cliniche 'Mario Serio'

Recapiti

letizia.canu(AT)unifi.it

Letizia CANU

Curriculum

Letizia Canu, MD, PhD

Nata a Prato, 8 Febbraio 1982

Nazionalità: Italiana

Indirizzo: Dipartimento di Scienze Biomediche Sperimentali e Cliniche “Mario Serio”, Università degli Studi di Firenze, Viale Pieraccini 6, 50139 Firenze – Italia

FORMAZIONE

2009 Laurea in Medicina e Chirurgia presso Università degli Studi di Firenze 108/110 con tesi dal titolo “Gli effetti anti proliferativi del Rosiglitazone nel carcinoma corticosurrenalico: risultati in vitro ed in vivo”

2016 Specializzazione in Endocrinologia presso Università degli Studi di Firenze: 70/70 cum laude con tesi dal titolo “La terapia del feocromocitoma/paraganglioma metastatico: un problema irrisolto”.

2019 Dottorato di Ricerca in Scienze Biomediche con tesi dal titolo “Feocromocitoma/paraganglioma: aspetti radiologici ed associazione con secondi tumori".

POSIZIONE ATTUALE, CARRIERA ACCADEMICA

2016-2021 Assegno di Ricerca assistenziale presso la SOD di Endocrinologia dell’Azienda Opsedaliero Universitaria di Careggi

2016-2019 Dottorato di Ricerca con attività assistenziale in Biotecnologie Endocrinologiche, molecolari e rigenerative presso il Dipartimento di Scienze Biomediche Sperimentali e Cliniche dell’Università degli Studi di Firenze

Da Settembre 2021 RTDA con assistenza presso la SOD di Endocrinologia dell’Azienda Opsedaliero Universitaria di Careggi

METRICHE

N=70 articoli pubblicati su riviste Internazionali (IF: 347.684; mean IF: 5.893)

N=9 pubblicati in riviste Italiane, n=4 capitoli di un libro

N>100 abstracts a Congressi Nazionali ed Internazionali

Scopus: H-index = 24; Citazioni = 1714

PARTECIPAZIONE A SOCIETÀ SCIENTIFICHE

Membro di European network for the study of Adrenal Tumor (ENS@T); Membro della Società Italiana di Endocrinologia (SIE); Membro di European Society of Endocrinology (ESE); Membro della Associazione Medici Endocrinologi (AME); Membro della commissione scientifica del Club Endocrinologia Giovane in Italia (EnGioI) dal 26/09/2015 al 31/05/2019; Referente per il centro Italia del gruppo giovani di AME dal 15/02/2021 ad oggi; Membro del comitato editorale dell’Endocrinologo dal 05/10/2023; Segretario del Club Surrene della SIE dal 25/10/2023

ATTIVITÀ EDITORIALE

2018 - 2022 Membro dell’Editorial Board del Journal of Endocrinological Investigation (JEI)

2021 -2022 Review Editor della rivista Frontiers in Endocrinology

Reviewer per molte riviste scientifiche (Cancers, Current Trends in Internal Medicine, Endocrine, Endocrine Connection, European Journal of Endocrinology, Frontiers in Endocrinology, Genetics in Medicine, Journal of Current Trends in Internal Medicine, Journal of Clinical Endocrinology & Metabolism, Journal of Endocrinological Investigation, Journal of Medical Genetics, Journal of Surgical, Endocrinology, OncoTargets and Therapy)

INSEGNAMENTO (dal 2016 ad oggi)

Correlatore tesi in Medicina e Chirurgia (n14)

Attività di insegnamento Scuola di specializzazione in Endocrinolgia

Attività di tutoraggio Corso di Laurea in Medicina e Chirurgia

PUBBLICAZIONI SELEZIONATE (2010-2023)

Canu L, …, Mannelli M. Pitfalls in Genetic Analysis of Pheochromocytomas/Paragangliomas: Case Report. J Clin Endocrinol Metab. 2014;99(7):2321-6. doi: 10.1210/jc.2013-4453. IF=5.399
Papathomas TG, …, Canu L, …, de Krijger RR. SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T). Mod Pathol. 2015;28(6):807-21. doi: 10.1038/modpathol.2015.41. IF=5.988
Salvianti F*, Canu L*, …, Pinzani P and Luconi M. New insights in the clinical and translational relevance of miR483-5p in adrenocortical cancer. Oncotarget. 2017;8(39):65525-65533. doi: 10.18632/oncotarget.19118. IF=5.168. *These authors have equally contributed to the work
Canu L, …, Timmers HJLM. CT characteristics of pheochromocytoma - Relevance for the evaluation of adrenal incidentaloma. J Clin Endocrinol Metab. 2019;104(2):312-318. doi: 10.1210/jc.2018-01532. IF=5.399
Castinetti F, …, Canu L, …, Baudin E. Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study. Lancet Diabetes Endocrinol. 2019;7(3):213-220. doi: 10.1016/S2213-8587(18)30336-X. IF=25.34
Hescot S, …, Canu L, …, Baudin E; European Network for the Study of Adrenal Tumors (ENS@T). Prognosis of Malignant Pheochromocytoma and Paraganglioma (MAPP-Prono Study): A European Network for the Study of Adrenal Tumors Retrospective Study. J Clin Endocrinol Metab. 2019;104(6):2367-2374. doi: 10.1210/jc.2018-01968. IF= 5.399
Rao D, …, Canu L, …, Timmers HJLM. Impact of 123 I_MIBG scintigraphy on clinical decision making in pheochromocytoma and paraganglioma. J Clin Endocrinol Metab. 2019;jc.2018-02355. doi: 10.1210/jc.2018-02355. IF= 5.399
Calsina B, …, Canu L, …, Robledo M. Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma. Theranostics 2019;9(17):4946-4958. doi: 10.7150/thno.35458. IF=8.579
Altieri B, …, Canu L, …, Ronchi CL. Effects of Germline CYP2W1*6 and CYP2B6*6 Single Nucleotide Polymorphisms on Mitotane Treatment in Adrenocortical Carcinoma: A Multicenter ENSAT Study. Cancers (Basel). 2020;12(2):359. doi: 10.3390/cancers12020359. IF=6.126
Doghman-Bouguerra M, …, Canu L, …, Lalli E. Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC. Cancers (Basel). 2020;12(3):689. doi: 10.3390/cancers12030689. IF= 6.126
De Filpo G, …, Canu L. Germline Mutation in KIF1Bβ Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma. Int J Endocrinol. 2020;3671396. doi: 10.1155/2020/3671396. IF=2.299
De Filpo G, …, Canu L. Management and outcome of metastatic pheochromocytomas/paragangliomas: an overview. J Endocrinol Invest. 2020. doi: 10.1007/s40618-020-01344-z. IF=3.397
Bancos I, …, Canu L, …, Arlt W; ENSAT EURINE-ACT Investigators. Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study. Lancet Diabetes Endocrinol. 2020;8(9):773-781.doi: 10.1016/S2213-8587(20)30218-7. IF=25.340
Cantini G, Canu L, …, Luconi M. Prognostic and monitoring value of circulating tumour cells in adrenocortical carcinoma: a preliminary monocentric study. Cancers 2020, 12(11):E3176. doi: 10.3390/cancers12113176. IF=6.126
Crona J, …, Canu L, …, Beuschlein F. ENSAT Registry-Based Randomized Clinical Trials for Adrenocortical Carcinoma. Eur J Endocrinol. 2020:EJE-20-0800.R1. doi: 10.1530/EJE-20-0800. IF=5.308
De Filpo G, …, Canu L. Adrenocortical carcinoma: current treatment options. Curr Opin Oncol. 2021;33(1):16-22. doi: 10.1097/CCO.0000000000000695. IF=3.370
Murakami M, …, Canu L, …, Beuschlein F. Mass Spectrometry Imaging Identifies Metabolic Patterns Associated with Malignant Potential in Pheochromocytoma and Paraganglioma. Eur J Endocrinol. 2021:EJE-20-1407.R1. doi: 10.1530/EJE-20-1407. IF= 5.308
Velema MS, Canu L, …, Deinum J; SPARTACUS Investigators. Volumetric evaluation of CT images of adrenal glands in primary aldosteronism. J Endocrinol Invest. 2021. doi: 10.1007/s40618-021-01540-5. IF= 3.397
Basile V, …, Canu L, …, Terzolo M. What Is the Optimal Duration of Adjuvant Mitotane Therapy in Adrenocortical Carcinoma? An Unanswered Question. J Pers Med. 2021;11(4):269. doi: 10.3390/jpm11040269. IF= 4.433
Cantini G, …, Canu L, …, Luconi M. Circulating fascin 1 as a promising prognostic marker in adrenocortical cancer. Front Endocrinol (Lausanne). 2021;12:698862. doi: 10.3389/fendo.2021.698862. IF=5.468
De Filpo G, …, Canu L. Management and outcome of metastatic pheochromocytomas/paragangliomas: a monocentric experience. J Endocrinol Invest. 2021. doi: 10.1007/s40618-021-01629-x. IF=3.16
Monteagudo M, …, Canu L, …, Robledo M. Analysis of telomere maintenance related genes reveals nop10 as a new metastatic-risk marker in PPGL. Cancers (Basel). 2021 Sep 23;13(19):4758. doi: 10.3390/cancers13194758. IF= 6.639
Cantini G, …, Canu L, …, Maggi M and Luconi M. Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression. J Pers Med. 2021 Oct 27;11(11):1097. doi: 10.3390/jpm11111097. IF= 4.453
Elhassan YS, …, Canu L, …, Ronchi CL. S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study. Eur J Endocrinol. 2021 Nov 30;186(1):25-36. doi: 10.1530/EJE-21-0510. IF=6.341
Canu L, …, Reimondo G. A Multicenter Epidemiological Study on Second Malignancy in Non-Syndromic Pheochromocytoma/Paraganglioma Patients in Italy. Cancers (Basel). 2021 Nov 20;13(22):5831. doi: 10.3390/cancers13225831. IF=6.639
Prete A, …, Canul L, …, Arlt W; ENSAT EURINE-ACT Investigators*; ENSAT EURINE-ACT Investigators. Cardiometabolic Disease Burden and Steroid Excretion in Benign Adrenal Tumors: A Cross-Sectional Multicenter Study. Ann Intern Med 2022;175(3):325-334. doi: 10.7326/M21-1737. IF= 25.391
Canu L, …, Peri A. Case Report: Adrenocortical Oncocytoma in a Patient with a Previous Contralateral Adrenalectomy for a Cortisol-Secreting Adenoma. Front Surg. 2022 19;9:897967. doi: 10.3389/fsurg.2022.897967. IF= 2.568
Provenzano A, …, Canu L. Novel Germline PHD2 Variant in a Metastatic Pheochromocytoma and Chronic Myeloid Leukemia, but in the Absence of Polycythemia. Medicina (Kaunas). 202217;58(8):1113. doi: 10.3390/medicina58081113. IF= 2.985
Fei L, … Canu L, … Luconi M. Carbonic anhydrases III and IX are new players in the crosstalk between adrenocortical carcinoma and its altered adipose microenvironment. J Endocrinol Invest. 2023. doi: 10.1007/s40618-023-02008-4. IF= 4.256
Mellid S, … Canu L, … Cascón A. Co-occurrence of mutations in NF1 and other susceptibility genes in pheochromocytoma and paraganglioma. Front Endocrinol (Lausanne). 2023;13:1070074. doi: 10.3389/fendo.2022.1070074. IF= 6.055
Luconi M, … Canu L, … Nesi G. Prognostic Value of Microscopic Tumor Necrosis in Adrenal Cortical Carcinoma. Endocr Pathol. 2023. doi: 10.1007/s12022-023-09760-6. IF=3.943
Puglisi S, … Canu L, … Terzolo M. New findings on presentation and outcome of patients with adrenocortical cancer: results from a national cohort study. J Clin Endocrinol Metab. 2023:dgad199. doi: 10.1210/clinem/dgad199. IF=6.134
Martinelli S, … Canu L, … Rapizzi E. Tumour microenvironment in pheochromocytoma and paraganglioma. Front Endocrinol (Lausanne). 2023;14:1137456. doi: 10.3389/fendo.2023.1137456. IF= 6.055
De Filpo G, … Canu L. Hemodynamic parameters in patients undergoing surgery for pheochromocytoma/paraganglioma: a retrospective study. World J Surg Onco. 2023;21(1):192. doi: 10.1186/s12957-023-03072-z. IF= 2.754
Amore F, …, Canu L, Rapizzi E. The aggressiveness of SDHB deficient chromaffin cells is reduced when their bioelectrical properties are restored by glibenclamide. Endocr Relat Cancer. 2023 Jul 1:ERC-23-0167. doi: 10.1530/ERC-23-0167. IF= 3.9
Amore F, …Canu L, …, Rapizzi E. The aggressiveness of succinate dehydrogenase subunit B-deficient chromaffin cells is reduced when their bioelectrical properties are restored by glibenclamide. Endocr Relat Cancer. 2023;30(10):e230167. doi: 10.1530/ERC-23-0167. IF= 3.9

Letizia CANU

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Canu, Letizia; Sparano, Clotilde; Naletto, Lara; De Filpo, Giuseppina; Cantini, Giulia; Rapizzi, Elena; Martinelli, Serena; Ercolino, Tonino; Cioppi, Francesca; Fantoni, Alessandro; Zanatta, Lorenzo; Terreni, Alessandro; Mannelli, Massimo; Luconi, Michaela; Maggi, Mario; Lotti, Francesco (In corso di stampa). Hypogonadism and sexual function in men affected by adrenocortical carcinoma under mitotane therapy. FRONTIERS IN ENDOCRINOLOGY, vol. 14, pp. 0-0, ISSN:1664-2392 DOI

Canu, Letizia; Perigli, Giuliano; Badii, Benedetta; Santi, Raffaella; Nesi, Gabriella; Pradella, Silvia; Maggi, Mario; Peri, Alessandro (In corso di stampa). Case Report: Adrenocortical Oncocytoma in a Patient with a Previous Contralateral Adrenalectomy for a Cortisol-Secreting Adenoma. FRONTIERS IN SURGERY, vol. 9, pp. 0-0, ISSN:2296-875X DOI

Serena Martinelli, Giulia Cantini, Arianna Pia Propato, Daniele Bani, Daniele Guasti, Patrizia Nardini, Laura Calosi, Tommaso Mello, Nicole Bechmann, Giovanna Danza, Fabio Villanelli, Letizia Canu, Mario Maggi, Massimo Mannelli, Elena Rapizzi, Michaela Luconi (In corso di stampa). The 3D in vitro Adrenoid cell model recapitulates the complexity of the adrenal gland. SCIENTIFIC REPORTS, vol. 14, pp. ...-..., ISSN:2045-2322 DOI

Serena Martinelli ,Alessandro Rolfo, Carlotta Pace, Letizia Canu, Anna Maria Nuzzo, Domenica Giuffrida, Pietro Gaglioti, Tullia Todros (2024). Anatomical and functional changes of the fetal adrenal gland in intrauterine growth restriction. INTERNATIONAL JOURNAL OF GYNAECOLOGY AND OBSTETRICS, pp. 0-0, ISSN:1879-3479 DOI

Puglisi, Soraya; Calabrese, Anna; Ferraù, Francesco; Violi, Maria Antonia; Laganà, Marta; Grisanti, Salvatore; Ceccato, Filippo; Scaroni, Carla; Di Dalmazi, Guido; Stigliano, Antonio; Altieri, Barbara; Canu, Letizia; Loli, Paola; Pivonello, Rosario; Arvat, Emanuela; Morelli, Valentina; Perotti, Paola; Basile, Vittoria; Berchialla, Paola; Urru, Sara; Fiori, Cristian; Porpiglia, Francesco; Berruti, Alfredo; Pia, Anna; Reimondo, Giuseppe; Cannavò, Salvatore; Terzolo, Massimo (2023). New Findings on Presentation and Outcome of Patients With Adrenocortical Cancer: Results From a National Cohort Study. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 108, pp. 2517-2525, ISSN:0021-972X DOI

Terzolo M, Fassnacht M, Perotti P, Libé R, Kastelan D, Lacroix A, Arlt W, Haak HR, Loli P, Decoudier B, Lasolle H, Quinkler M, Haissaguerre M, Chabre O, Caron P, Stigliano A, Giordano R, Zatelli MC, Bancos I, Fragoso MCBV, Canu L, Luconi M, Puglisi S, Basile V, Reimondo G, Kroiss M, Megerle F, Hahner S, Kimpel O, Dusek T, Nölting S, Bourdeau I, Chortis V, Ettaieb MH, Cosentini D, Grisanti S, Baudin E, Berchialla P, Bovis F, Sormani MP, Bruzzi P, Beuschlein F, Bertherat J, Berruti A. (2023). Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study. THE LANCET DIABETES & ENDOCRINOLOGY, vol. ..., pp. 720-730, ISSN:2213-8587 DOI

Amore, Francesca; Garella, Rachele; Santi, Alice; Guasti, Daniele; Martinelli, Serena; Canu, Letizia; Bani, Daniele; Neuzil, Jiri; Maggi, Mario; Squecco, Roberta; Rapizzi, Elena (2023). The aggressiveness of succinate dehydrogenase subunit B-deficient chromaffin cells is reduced when their bioelectrical properties are restored by glibenclamide. ENDOCRINE-RELATED CANCER, vol. 30, pp. 0-0, ISSN:1351-0088 DOI

Fei L, Cantini G, Nocentini A, Nardini P, Catarinicchia S, Canu L, Ercolino T, Quartararo G, Nesi G, Gacci M, Maggi M, Hantel C, Mannelli M, Supuran CT, Luconi M (2023). Carbonic anhydrases III and IX are new players in the crosstalk between adrenocortical carcinoma and its altered adipose microenvironment. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, pp. 1-10, ISSN:0391-4097 DOI

De Filpo, Giuseppina; Parenti, Gabriele; Sparano, Clotilde; Rastrelli, Giulia; Rapizzi, Elena; Martinelli, Serena; Amore, Francesca; Badii, Benedetta; Paolo, Prosperi; Ercolino, Tonino; Mannelli, Massimo; Maggi, Mario; Canu, Letizia (2023). Hemodynamic parameters in patients undergoing surgery for pheochromocytoma/paraganglioma: a retrospective study. WORLD JOURNAL OF SURGICAL ONCOLOGY, vol. 21, pp. 192-192, ISSN:1477-7819 DOI

Luconi M, Cantini G, van Leeuwaarde RS, Roebaar R, Fei L, Propato AP, Santi R, Ercolino T, Mannelli M, Canu L, de Krijger RR, Nesi G. (2023). Prognostic Value of Microscopic Tumor Necrosis in Adrenal Cortical Carcinoma. ENDOCRINE PATHOLOGY, pp. 1-10, ISSN:1046-3976 DOI

Martinelli, Serena; Amore, Francesca; Canu, Letizia; Maggi, Mario; Rapizzi, Elena (2023). Tumour microenvironment in pheochromocytoma and paraganglioma. FRONTIERS IN ENDOCRINOLOGY, vol. 14, pp. 1137456-1137456, ISSN:1664-2392 DOI

Cantini, Giulia; Niccolai, Elena; Canu, Letizia; Di Gloria, Leandro; Baldi, Simone; Propato, Arianna Pia; Fei, Laura; Nannini, Giulia; Puglisi, Soraya; Nesi, Gabriella; Ramazzotti, Matteo; Amedei, Amedeo; Luconi, Michaela (2023). Intratumour microbiota modulates adrenocortical cancer responsiveness to mitotane. ENDOCRINE-RELATED CANCER, vol. 30, pp. 0-0, ISSN:1351-0088 DOI

van Haalen, F. M.; Kaya, M.; Pelsma, I. C. M.; Dekkers, O. M.; Biermasz, N. R.; Cannegieter, S. C.; Huisman, M. V.; van Vlijmen, B. J. M.; Feelders, R. A.; Klok, F. A.; Pereira, A. M.; Stochholm, K.; Fliers, E.; Castinetti, F.; Brue, T.; Bertherat, J.; Scaroni, C.; Colao, A.; Giordano, R.; Druce, M. R.; Beckers, A.; Spranger, J.; Driessens, N.; Maiter, D.; Feldt-Rasmussen, U.; Feelders, R.; Webb, S. M.; Dattani, M.; Husebye, E.; Zilaitiene, B.; Gaztambide, S.; Gatto, F.; Ferone, D.; Persani, L.; Chiodini, I.; Höybye, C.; Pereira, A. M.; Biermasz, N. R.; Klok, F. A.; Dekkers, O. M.; Meijer, O. C.; Reincke, M.; Vila, G.; Perry, C.; Heck, A.; Stancampiano, M. R.; van de Ven, A.; Johannsson, G.; Ragnarsson, O.; Tóth, M.; Volke, V.; Toumba, M.; Canu, L.; Vojtková, J.; Al-Mrayat, M.; Fassnacht, M.; Detomas, M.; Karavitaki, N.; van der Klauw, M. M.; Groselj, U.; Elenkova, A.; Unuane, D.; null, null (2022). Current clinical practice for thromboprophylaxis management in patients with Cushing’s syndrome across reference centers of the European Reference Network on Rare Endocrine Conditions (Endo-ERN). ORPHANET JOURNAL OF RARE DISEASES, vol. 17, pp. 0-0, ISSN:1750-1172 DOI

De Filpo G.; Cantini G.; Rastrelli G.; Vannini G.; Ercolino T.; Luconi M.; Mannelli M.; Maggi M.; Canu L. (2022). Management and outcome of metastatic pheochromocytomas/paragangliomas: a monocentric experience. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol. 45, pp. 149-157, ISSN:0391-4097 DOI

Mellid, Sara; Gil, Eduardo; Letón, Rocío; Caleiras, Eduardo; Honrado, Emiliano; Richter, Susan; Palacios, Nuria; Lahera, Marcos; Galofré, Juan C; López-Fernández, Adriá; Calatayud, Maria; Herrera-Martínez, Aura D; Galvez, María A; Matias-Guiu, Xavier; Balbín, Milagros; Korpershoek, Esther; Lim, Eugénie S; Maletta, Francesca; Lider, Sofia; Fliedner, Stephanie M J; Bechmann, Nicole; Eisenhofer, Graeme; Canu, Letizia; Rapizzi, Elena; Bancos, Irina; Robledo, Mercedes; Cascón, Alberto (2022). Co-occurrence of mutations in NF1 and other susceptibility genes in pheochromocytoma and paraganglioma. FRONTIERS IN ENDOCRINOLOGY, vol. 13, pp. 1070074-1070078, ISSN:1664-2392 DOI

Elhassan Y.S.; Altieri B.; Berhane S.; Cosentini D.; Calabrese A.; Haissaguerre M.; Kastelan D.; Fragoso M.C.B.V.; Bertherat J.; Al Ghuzlan A.; Haak H.; Boudina M.; Canu L.; Loli P.; Sherlock M.; Kimpel O.; Lagana M.; Sitch A.J.; Arlt W.; Kroiss M.; Terzolo M.; Berruti A.; Deeks J.J.; Libe R.; Fassnacht M.; Ronchi C.L. (2022). S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study. EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 186, pp. 25-36, ISSN:0804-4643 DOI

Laganà, M.; Grisanti, S.; Ambrosini, R.; Cosentini, D.; Abate, A.; Zamparini, M.; Ferrari, V.D.; Gianoncelli, A.; Turla, A.; Canu, L.; Terzolo, M.; Tiberio, G.A.M.; Sigala, S.; Berruti, A. (2022). Phase II study of cabazitaxel as second-third line treatment in patients with metastatic adrenocortical carcinoma. ESMO OPEN, vol. 7, pp. 0-0, ISSN:2059-7029 DOI

Provenzano, Aldesia; Chetta, Massimiliano; De Filpo, Giuseppina; Cantini, Giulia; La Barbera, Andrea; Nesi, Gabriella; Santi, Raffaella; Martinelli, Serena; Rapizzi, Elena; Luconi, Michaela; Maggi, Mario; Mannelli, Massimo; Ercolino, Tonino; Canu, Letizia (2022). Novel Germline PHD2 Variant in a Metastatic Pheochromocytoma and Chronic Myeloid Leukemia, but in the Absence of Polycythemia. MEDICINA, vol. 58, pp. 0-0, ISSN:1010-660X DOI

De Filpo G.; Mannelli M.; Canu L. (2021). Adrenocortical carcinoma: Current treatment options. CURRENT OPINION IN ONCOLOGY, vol. 33, pp. 16-22, ISSN:1040-8746 DOI

De Filpo G, Maggi M, Mannelli M, Canu L. (2021). Management and outcome of metastatic pheochromocytomas/paragangliomas: an overview. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol. 44, pp. 15-25, ISSN:1720-8386 DOI

Murakami M.; Sun N.; Greunke C.; Feuchtinger A.; Kircher S.; Deutschbein T.; Papathomas T.; Bechmann N.; Wallace P.W.; Peitzsch M.; Korpershoek E.; Friemel J.; Gimenez-Roqueplo A.-P.; Robledo M.; Timmers H.J.L.M.; Canu L.; Weber A.; de Krijger R.R.; Fassnacht M.; Knosel T.; Kirchner T.; Reincke M.; Karl Walch A.; Kroiss M.; Beuschlein F. (2021). Mass spectrometry imaging identifies metabolic patterns associated with malignant potential in pheochromocytoma and paraganglioma. EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 185, pp. 179-191, ISSN:0804-4643 DOI

Crona J, Baudin E, Terzolo M, Chrisoulidou A, Angelousi AG, Ronchi CL, Lamas C, Nieveen van Dijkum E, Ceccato F, Borson-Chazot F, Reimondo G, Tiberi GA, Ettaieb H, Kiriakopoulos A, Canu L, Kastelan D, Osher E, Yiannakopoulou E, Arnaldi G, Assie G, Paiva I, Bourdeau I, Newell-Price J, Nowak KM, Romero MT, De Martino MC, Bugalho MJ, Sherlock M, Vantyghem MC, Dennedy MC, Loli P, Rodien P, Feelders RA, de Krijger RR, Van Slycke S, Aylwin S, Morelli V, Vroonen L, Shafigullina Z, Bancos I, Trofimiuk-Müldner M, Quinkler M, Luconi M, Kroiss M, Naruse M, Igaz P, Mihai R, Della Casa S, Berruti A, Fassnacht M, Beuschlein F. (2021). ENSAT Registry-Based Randomized Clinical Trials for Adrenocortical Carcinoma. EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 184, pp. 51-59, ISSN:1479-683X DOI

Cantini G.; Fei L.; Canu L.; Lazzeri E.; Sottili M.; Francalanci M.; Angelotti M.L.; De Filpo G.; Ercolino T.; Gelmini S.; Mangoni M.; Nesi G.; Hantel C.; Mannelli M.; Maggi M.; Luconi M. (2021). Stimulated expression of CXCL12 in adrenocortical carcinoma by the ppargamma ligand rosiglitazone impairs cancer progression. JOURNAL OF PERSONALIZED MEDICINE, vol. 11, pp. 1-7, ISSN:2075-4426 DOI

Velema M.S.; Canu L.; Dekkers T.; Hermus A.R.M.M.; Timmers H.J.L.M.; Schultze Kool L.J.; Groenewoud H.J.M.M.; Jacobs C.; Deinum J.; Prejbisz A.; Kool L.J.S.; Velema M.; Spiering W.; Kolodziejczyk-Kruk S.; Arntz M.; Kadziela J.; Langenhuijsen J.F.; Kerstens M.N.; van den Meiracker A.H.; van den Born B.J.; Sweep F.C.G.J.; Januszewicz A.; Ligthart-Naber A.F.; Makai P.; van der Wilt G.J.; Lenders J.W.M. (2021). Volumetric evaluation of CT images of adrenal glands in primary aldosteronism. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol. 44, pp. 2359-2366, ISSN:0391-4097 DOI

Canu L.; Puglisi S.; Berchialla P.; De Filpo G.; Brignardello F.; Schiavi F.; Ferrara A.M.; Zovato S.; Luconi M.; Pia A.; Appetecchia M.; Arvat E.; Letizia C.; Maccario M.; Parasiliti-Caprino M.; Altieri B.; Faggiano A.; Modica R.; Morelli V.; Arosio M.; Verga U.; Pellegrino M.; Petramala L.; Concistre A.; Razzore P.; Ercolino T.; Rapizzi E.; Maggi M.; Stigliano A.; Burrello J.; Terzolo M.; Opocher G.; Mannelli M.; Reimondo G. (2021). A multicenter epidemiological study on second malignancy in non-syndromic pheochromocytoma/paraganglioma patients in Italy. CANCERS, vol. 13, pp. 5831-5845, ISSN:2072-6694 DOI

Monteagudo M.; Martinez P.; Leandro-Garcia L.J.; Martinez-Montes A.M.; Calsina B.; Pulgarin-Alfaro M.; Diaz-Talavera A.; Mellid S.; Leton R.; Gil E.; Perez-Martinez M.; Megias D.; Torres-Ruiz R.; Rodriguez-Perales S.; Gonzalez P.; Caleiras E.; Jimenez-Villa S.; Roncador G.; Alvarez-Escola C.; Regojo R.M.; Calatayud M.; Guadalix S.; Curras-Freixes M.; Rapizzi E.; Canu L.; Nolting S.; Remde H.; Fassnacht M.; Bechmann N.; Eisenhofer G.; Mannelli M.; Beuschlein F.; Quinkler M.; Rodriguez-Antona C.; Cascon A.; Blasco M.A.; Montero-Conde C.; Robledo M. (2021). Analysis of telomere maintenance related genes reveals NOP10 as a new metastatic-risk marker in pheochromocytoma/paraganglioma. CANCERS, vol. 13, pp. 4758-4779, ISSN:2072-6694 DOI

Basile, Vittoria; Puglisi, Soraya; Altieri, Barbara; Canu, Letizia; Libè, Rossella; Ceccato, Filippo; Beuschlein, Felix; Quinkler, Marcus; Calabrese, Anna; Perotti, Paola; Berchialla, Paola; Dischinger, Ulrich; Megerle, Felix; Baudin, Eric; Bourdeau, Isabelle; Lacroix, André; Loli, Paola; Berruti, Alfredo; Kastelan, Darko; Haak, Harm R; Fassnacht, Martin; Terzolo, Massimo (2021). What Is the Optimal Duration of Adjuvant Mitotane Therapy in Adrenocortical Carcinoma? An Unanswered Question. JOURNAL OF PERSONALIZED MEDICINE, vol. 11, pp. 24-28, ISSN:2075-4426 DOI

Murro V.; Lippera M.; Mucciolo D.P.; Canu L.; Ercolino T.; De Filpo G.; Giorgio D.; Traficante G.; Sodi A.; Virgili G.; Giansanti F. (2021). Outcome and genetic analysis of patients affected by retinal capillary hemangioblastoma in von hippel lindau syndrome. MOLECULAR VISION, vol. 27, pp. 542-554, ISSN:1090-0535

Cantini G, Fei L, Canu L, De Filpo G, Ercolino T, Nesi G, Mannelli M, Luconi M (2021). Circulating Fascin 1 as a Promising Prognostic Marker in Adrenocortical Cancer. FRONTIERS IN ENDOCRINOLOGY, pp. 1-7, ISSN:1664-2392 DOI

De Filpo G, Contini E, Serio V, Valeri A, Chetta M, Guasti D, Bani D, Mannelli M, Rapizzi E, Luconi M, Maggi M, Ercolino T, Canu L. (2020). Germline Mutation in KIF1Bβ Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, vol. 2020, pp. 3671396--, ISSN:1687-8345 DOI

Sarkadi B, Meszaros K, Krencz I, Canu L, Krokker L, Zakarias S, Barna G, Sebestyen A, Papay J, Hujber Z, Butz H, Darvasi O, Igaz P, Doczi J, Luconi M, Chinopoulos C, Patocs A. (2020). Glutaminases as a Novel Target for SDHB-Associated Pheochromocytomas/Paragangliomas.. CANCERS, vol. 12, pp. 599-625, ISSN:2072-6694 DOI

Bancos I.; Taylor A.E.; Chortis V.; Sitch A.J.; Jenkinson C.; Davidge-Pitts C.J.; Lang K.; Tsagarakis S.; Macech M.; Riester A.; Deutschbein T.; Pupovac I.D.; Kienitz T.; Prete A.; Papathomas T.G.; Gilligan L.C.; Bancos C.; Reimondo G.; Haissaguerre M.; Marina L.; Grytaas M.A.; Sajwani A.; Langton K.; Ivison H.E.; Shackleton C.H.L.; Erickson D.; Asia M.; Palimeri S.; Kondracka A.; Spyroglou A.; Ronchi C.L.; Simunov B.; Delivanis D.A.; Sutcliffe R.P.; Tsirou I.; Bednarczuk T.; Reincke M.; Burger-Stritt S.; Feelders R.A.; Canu L.; Haak H.R.; Eisenhofer G.; Dennedy M.C.; Ueland G.A.; Ivovic M.; Tabarin A.; Terzolo M.; Quinkler M.; Kastelan D.; Fassnacht M.; Beuschlein F.; Ambroziak U.; Vassiliadi D.A.; O'Reilly M.W.; Young W.F.; Biehl M.; Deeks J.J.; Arlt W.; Glockner S.; Sinnott R.O.; Stell A.; Fragoso M.C.; Pupovac I.D.; Cazenave S.; Bertherat J.; Libe R.; Brugger C.; Hahner S.; Kroiss M.; Ronchi C.L.; Vassiliadi D.A.; Basile V.; Ingargiola E.; Mannelli M.; Ettaieb H.; Haak H.R.; Kerkhofs T.M.; Feelders R.A.; Hofland J.; Hofland L.J.; Grytaas M.A.; Husebye E.S.; Ueland G.A.; Zawierucha M.; Paiva I.; Dennedy M.C.; Sherlock M.; Crowley R.K.; Deeks J.J.; Sitch A.J.; Giligan L.C.; Hughes B.A.; Ivison H.E.; Manolopoulos K.; O'Neil D.M.; O'Reilly M.W.; Papathomas T.G.; Shackleton C.H.L.; Taylor A.E.; Sutcliffe R.P.; Guest P.; Skordilis K.; Chang A.; Davidge-Pitts C.J.; Delivanis D.A.; Natt N.; Nippoldt T.B.; Thomas M.; Young W.F. (2020). Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study. THE LANCET DIABETES & ENDOCRINOLOGY, vol. 8, pp. 773-781, ISSN:2213-8587 DOI

Doghman-Bouguerr Ma, Finetti P, Durand N, Parise IZS, Sbiera S, Cantini G, Canu L, Hescot S, Figueiredo MOM, Komechen H, Sbiera I, Nesi G, Paci A, Al-Ghuzlan A, Birnbaum D, Baudin E, Luconi M, Fassnacht M, Figueiredo BC, Bertucci F, Lalli E (2020). Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC. CANCERS, vol. 12, pp. 689-708, ISSN:2072-6694 DOI

Giuseppina De Filpo, Antonio Cilotti, Silvia Pradella, Giulia Cantini, Tonino Ercolino, Gabriella Nesi, Massimo Mannelli, Mario Maggi, Letizia Canu (2020). SDHx and Non-Chromaffin Tumors: A Mediastinal Germ Cell Tumor Occurring in a Young Man with Germline SDHB Mutation. MEDICINA, pp. 0-0, ISSN:1010-660X DOI

Cantini G, Canu L, Armignacco R, Salvianti F, De Filpo G, Ercolino T, Nesi G, Maggi M, Mannelli M, Pinzani P, Luconi M (2020). Prognostic and monitoring value of circulating tumour cells in adrenocortical carcinoma: a preliminary monocentric study.. CANCERS, vol. 12, pp. xx-xx, ISSN:2072-6694 DOI

Puglisi, Soraya; Calabrese, Anna; Basile, Vittoria; Ceccato, Filippo; Scaroni, Carla; Simeoli, Chiara; Torlontano, Massimo; Cannavò, Salvatore; Arnaldi, Giorgio; Stigliano, Antonio; Malandrino, Pasqualino; Saba, Laura; Altieri, Barbara; Della Casa, Silvia; Perotti, Paola; Berchialla, Paola; De Filpo, Giuseppina; Canu, Letizia; Loli, Paola; Reimondo, Giuseppe; Terzolo, Massimo (2019). Mitotane Concentrations Influence the Risk of Recurrence in Adrenocortical Carcinoma Patients on Adjuvant Treatment. JOURNAL OF CLINICAL MEDICINE, vol. 8, pp. 0-0, ISSN:2077-0383 DOI

Hescot S.; Curras-Freixes M.; Deutschbein T.; Van Berkel A.; Vezzosi D.; Amar L.; De La Fouchardiere C.; Valdes N.; Riccardi F.; Cao C.D.; Bertherat J.; Goichot B.; Beuschlein F.; Drui D.; Canu L.; Niccoli P.; Laboureau S.; Tabarin A.; Leboulleux S.; Calsina B.; Libe R.; Faggiano A.; Schlumberger M.; Borson-Chazot F.; Mannelli M.; Gimenez-Roqueplo A.-P.; Caron P.; Timmers H.J.L.M.; Fassnacht M.; Robledo M.; Borget I.; Baudin E. (2019). Prognosis of malignant pheochromocytoma and paraganglioma (MAPP-PronO study): A European network for the study of adrenal tumors retrospective study. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 104, pp. 2367-2374, ISSN:0021-972X DOI Accesso ONLINE all'editore

Chortis, Vasileios; Bancos, Irina; Nijman, Thomas; Gilligan, Lorna C; Taylor, Angela E; Ronchi, Cristina L; O'Reilly, Michael W; Schreiner, Jochen; Asia, Miriam; Riester, Anna; Perotti, Paola; Libé, Rosella; Quinkler, Marcus; Canu, Letizia; Paiva, Isabel; Bugalho, Maria J; Kastelan, Darko; Dennedy, M Conall; Sherlock, Mark; Ambroziak, Urszula; Vassiliadi, Dimitra; Bertherat, Jerome; Beuschlein, Felix; Fassnacht, Martin; Deeks, Jonathan J; Biehl, Michael; Arlt, Wiebke (2019). Urine steroid metabolomics as a novel tool for detection of recurrent adrenocortical carcinoma. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, pp. 0-0, ISSN:0021-972X DOI

Calsina B.; Castro-Vega L.J.; Torres-Perez R.; Inglada-Perez L.; Curras-Freixes M.; Roldan-Romero J.M.; Mancikova V.; Leton R.; Remacha L.; Santos M.; Burnichon N.; Lussey-Lepoutre C.; Rapizzi E.; Grana O.; Alvarez-Escola C.; de Cubas A.A.; Lanillos J.; Cordero-Barreal A.; Martinez-Montes A.M.; Bellucci A.; Amar L.; Fernandes-Rosa F.L.; Calatayud M.; Aller J.; Lamas C.; Sastre-Marcos J.; Canu L.; Korpershoek E.; Timmers H.J.; Lenders J.W.M.; Beuschlein F.; Fassnacht-Capeller M.; Eisenhofer G.; Mannelli M.; Al-Shahrour F.; Favier J.; Rodriguez-Antona C.; Cascon A.; Montero-Conde C.; Gimenez-Roqueplo A.-P.; Robledo M. (2019). Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/ mTOR axis in metastatic pheochromocytoma/ paraganglioma. THERANOSTICS, vol. 9, pp. 4946-4958, ISSN:1838-7640 DOI Accesso ONLINE all'editore

Letizia Canu (2019). Feocromocitoma/Paraganglioma: aspetti radiologici ed associazione con seconde neoplasie.. (Tutor: Massimo Mannelli)

Canu L.; Parenti G.; De Filpo G.; Mannelli M. (2019). Pheochromocytomas and paragangliomas as causes of endocrine hypertension. In: Letizia Canu, Gabriele Parenti, Giuseppina De Filpo, Massimo Mannelli. Pheochromocytomas and Paragangliomas as Causes of Endocrine Hypertension, pp. 0-0 Frontiers Media S.A.. DOI Accesso ONLINE all'editore

Poli G, Ruggiero C, Cantini G, Canu L, Baroni G, Armignacco R, Jouinot A, Santi R, Ercolino T, Ragazzon B, Assie G, Mannelli M, Nesi G, Lalli E, Luconi M. (2019). Fascin-1 is a Novel Prognostic Biomarker Associated with Tumor Invasiveness in Adrenocortical Carcinoma.. THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 104, pp. 1712-1724, ISSN:1945-7197 DOI

Rao D.; Van Berkel A.; Piscaer I.; Young W.F.; Gruber L.; Deutschbein T.; Fassnacht M.; Beuschlein F.; Spyroglou A.; Prejbisz A.; Hanus K.; Eisenhofer G.; Manelli M.; Canu L.; Lenders J.W.M.; Bancos I.; Timmers H.J.L.M. (2019). Impact of 123I-MIBG Scintigraphy on Clinical Decision-Making in Pheochromocytoma and Paraganglioma. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 104, pp. 3812-3820, ISSN:0021-972X DOI Accesso ONLINE all'editore

Castinetti F.; Waguespack S.G.; Machens A.; Uchino S.; Hasse-Lazar K.; Sanso G.; Else T.; Dvorakova S.; Qi X.P.; Elisei R.; Maia A.L.; Glod J.; Lourenco D.M.; Valdes N.; Mathiesen J.; Wohllk N.; Bandgar T.R.; Drui D.; Korbonits M.; Druce M.R.; Brain C.; Kurzawinski T.; Patocs A.; Bugalho M.J.; Lacroix A.; Caron P.; Fainstein-Day P.; Borson Chazot F.; Klein M.; Links T.P.; Letizia C.; Fugazzola L.; Chabre O.; Canu L.; Cohen R.; Tabarin A.; Spehar Uroic A.; Maiter D.; Laboureau S.; Mian C.; Peczkowska M.; Sebag F.; Brue T.; Mirebeau-Prunier D.; Leclerc L.; Bausch B.; Berdelou A.; Sukurai A.; Vlcek P.; Krajewska J.; Barontini M.; Vaz Ferreira Vargas C.; Valerio L.; Ceolin L.; Akshintala S.; Hoff A.; Godballe C.; Jarzab B.; Jimenez C.; Eng C.; Imai T.; Schlumberger M.; Grubbs E.; Dralle H.; Neumann H.P.; Baudin E. (2019). Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study. THE LANCET DIABETES & ENDOCRINOLOGY, vol. 7, pp. 213-220, ISSN:2213-8587 DOI Accesso ONLINE all'editore

Armignacco, Roberta; Cantini, Giulia; Canu, Letizia; Poli, Giada; Ercolino, Tonino; Mannelli, Massimo; Luconi, Michaela (2018). Adrenocortical carcinoma: the dawn of a new era of genomic and molecular biology analysis.. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol. 41, pp. 499-507, ISSN:1720-8386 DOI

Mannelli, Massimo*; Canu, Letizia; Ercolino, Tonino; Rapizzi, Elena; Martinelli, Serena; Parenti, Gabriele; De Filpo, Giuseppina; Nesi, Gabriella (2018). DIAGNOSIS of ENDOCRINE DISEASE: SDHx mutations: Beyond pheochromocytomas and paragangliomas. EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 178, pp. R11-R17, ISSN:0804-4643 DOI Accesso ONLINE all'editore

Perge, Pál; Decmann, Ábel; Pezzani, Raffaele; Bancos, Irina; Fassina, Ambrogio; Luconi, Michaela; Canu, Letizia; Tóth, Miklós; Boscaro, Marco; Patócs, Attila; Igaz, Peter (2018). Analysis of circulating extracellular vesicle-associated microRNAs in cortisol-producing adrenocortical tumors. ENDOCRINE, vol. 59, pp. 280-287, ISSN:1355-008X DOI Accesso ONLINE all'editore

Buitenwerf, Edward; Korteweg, Tijmen; Visser, Anneke; Haag, Charlotte Msc; Feelders, Richard A; Timmers, Henri J; Canu, Letizia; Haak, H R; Bisschop, Peter H; Eekhoff, E Marelise W; van der Kleij-Corssmit, Eleonora Pm; Krak, Nanda C; Rasenberg, Elise; van den Bergh, Janneke; Stoker, Jaap; Greuter, Marcel Jw; Dullaart, Robin P F; Links, Thera P; Kerstens, Michiel N (2018). Unenhanced CT imaging is highly sensitive to exclude pheochromocytoma: a multicenter study. EUROPEAN JOURNAL OF ENDOCRINOLOGY, pp. EJE-18-0006-EJE-18-0006, ISSN:0804-4643 DOI

Canu, Letizia; Armignacco, Roberta; Poli, Giada; Cantini, Giulia; Ercolino, Tonino; Mannelli, Massimo; Luconi, Michaela (2017). Caratterizzazione genomica del carcinoma surrenalico. L'ENDOCRINOLOGO, vol. 17, pp. 293-299, ISSN:1590-170X DOI

Salvianti, Francesca; Canu, Letizia; Poli, Giada; Armignacco, Roberta; Scatena, Cristian; Cantini, Giulia; Franco, Alessandra Di; Gelmini, Stefania; Ercolino, Tonino; Pazzagli, Mario; Nesi, Gabriella; Mannelli, Massimo; Pinzani, Pamela; Luconi, Michaela (2017). NEW INSIGHTS IN THE CLINICAL AND TRANSLATIONAL RELEVANCE OF miR483-5p IN ADRENOCORTICAL CANCER. ONCOTARGET, vol. 8, pp. 65525-65533., ISSN:1949-2553 DOI

Castinetti, Frederic; Maia, Ana Luiza; Peczkowska, Mariola; Barontini, Marta; Hasse-Lazar, Kornelia; Links, Thera P; Toledo, Rodrigo A; Dvorakova, Sarka; Mian, Caterina; Bugalho, Maria Joao; Zovato, Stefania; Alevizaki, Maria; Kvachenyuk, Andrei; Bausch, Birke; Loli, Paola; Bergmann, Simona R; Patocs, Attila; Pfeifer, Marija; Costa, Josefina Biarnes; von Dobschuetz, Ernst; Letizia, Claudio; Valk, Gerlof; Barczynski, Marcin; Czetwertynska, Malgorzata; Plukker, John T M; Sartorato, Paola; Zelinka, Tomas; Vlcek, Petr; Yaremchuk, Svetlana; Weryha, Georges; Canu, Letizia; Wohllk, Nelson; Sebag, Frederic; Walz, Martin K; Eng, Charis; Neumann, Hartmut P H (2017). The penetrance of MEN2 pheochromocytoma is not only determined byRETmutations. ENDOCRINE-RELATED CANCER, vol. 24, pp. L63-L67-L67, ISSN:1351-0088 DOI

D'Antongiovanni, Vanessa; Martinelli, Serena; Richter, Susan; Canu, Letizia; Guasti, Daniele; Mello, Tommaso; Romagnoli, Paolo; Pacak, Karel; Eisenhofer, Graeme; Mannelli, Massimo; Rapizzi, Elena (2017). The microenvironment induces collective migration in SDHB-silenced mouse pheochromocytoma spheroids. ENDOCRINE-RELATED CANCER, vol. 24, pp. 555-564, ISSN:1351-0088 DOI

Canu L.; Pradella S.; Rapizzi E.; Fucci R.; Valeri A.; Briganti V.; Giache V.; Parenti G.; Ercolino T.; Mannelli M. (2017). Sunitinib in the therapy of malignant paragangliomas: Report on the efficacy in a sdhb mutation carrier and review of the literature. ARCHIVES OF ENDOCRINOLOGY AND METABOLISM, vol. 61, pp. 90-97, ISSN:2359-3997 DOI

Santi R.; Rapizzi E.; Canu L.; Ercolino T.; Baroni G.; Fucci R.; Costa G.; Mannelli M.; Nesi G. (2017). Potential pitfalls of SDH immunohistochemical detection in paragangliomas and phaeochromocytomas harbouring germline SDHx gene mutation. ANTICANCER RESEARCH, vol. 37, pp. 805-812, ISSN:0250-7005 DOI

Poli, G; Cantini, G; Armignacco, R; Fucci, R; Santi, R; Canu, L; Nesi, G; Mannelli, M; Luconi, M (2016). Metformin as a new anti-cancer drug in adrenocortical carcinoma. ONCOTARGET, vol. 7, pp. 49636-49648, ISSN:1949-2553 DOI

Mannelli, Massimo; Parenti, Gabriele; Canu, Letizia; Stefani, Laura; Galanti, Giorgio (2016). Ipertensione ed esercizio fisico. L'ENDOCRINOLOGO, vol. 17, pp. 65-72, ISSN:1590-170X DOI

Mannelli, Massimo; Opocher, Giuseppe; Canu, Letizia (2016). Metodiche di dosaggio di metanefrine e catecolamine: rischi e variabili interpretative per i dosaggi effettuati in centri non specializzati. L'ENDOCRINOLOGO, vol. 17, pp. 107-108, ISSN:1590-170X DOI

Stigliano, A; Chiodini, I; Giordano, R; Faggiano, A; Canu, L; Della Casa, S; Loli, P; Luconi, M; Mantero, F; Terzolo, M. (2016). Management of adrenocortical carcinoma: a consensus statement of the Italian Society of Endocrinology (SIE).. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol. 39, pp. 103-121, ISSN:1720-8386 DOI

Poli, Giada; Ceni, Elisabetta; Armignacco, Roberta; Ercolino, Tonino; Canu, Letizia; Baroni, Gianna; Nesi, Gabriella; Galli, Andrea; Mannelli, Massimo; Luconi, Michaela (2015). 2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma. ONCOTARGET, vol. 6, pp. 5695-5706, ISSN:1949-2553 DOI

Rapizzi, Elena; Fucci, Rossella; Giannoni, Elisa; Canu, Letizia; Richter, Susan; Cirri, Paolo; Mannelli, Massimo (2015). Role of microenvironment on neuroblastoma SK-N-AS SDHB-silenced cell metabolism and function. ENDOCRINE-RELATED CANCER, vol. 22, pp. 409-417, ISSN:1351-0088 DOI Accesso ONLINE all'editore

Mannelli, Massimo; Rapizzi, Elena; Fucci, Rossella; Canu, Letizia; Ercolino, Tonino; Michaela, Luconi; Young William, F. (2015). 15 YEARS OF PARAGANGLIOMA: Metabolism and pheochromocytoma/paraganglioma. ENDOCRINE-RELATED CANCER, vol. 22, pp. 83-90, ISSN:1351-0088 DOI

Papathomas, Thomas G.; Oudijk, Lindsey; Persu, Alexandre; Gill, Anthony J.; Van Nederveen, Francien; Tischler, Arthur S.; Tissier, Frédérique; Volante, Marco; Matias-Guiu, Xavier; Smid, Marcel; Favier, Judith; Rapizzi, Elena; Libe, Rosella; Currás-Freixes, Maria; Aydin, Selda; Huynh, Thanh; Lichtenauer, Urs; Van Berkel, Anouk; Canu, Letizia; Domingues, Rita; Clifton-Bligh, Roderick J.; Bialas, Magdalena; Vikkula, Miikka; Baretton, Gustavo; Papotti, Mauro; Nesi, Gabriella; Badoual, Cécile; Pacak, Karel; Eisenhofer, Graeme; Timmers, Henri J.; Beuschlein, Felix; Bertherat, Jérôme; Mannelli, Massimo; Robledo, Mercedes; Gimenez-Roqueplo, Anne-Paule; Dinjens, Winand N.M.; Korpershoek, Esther; De Krijger, Ronald R. (2015). SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: A multicenter interobserver variation analysis using virtual microscopy: A Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T). MODERN PATHOLOGY, vol. 28, pp. 807-821, ISSN:0893-3952 DOI Accesso ONLINE all'editore

Canu L;Rapizzi E;Zampetti B;Fucci R;Nesi G;Richter S;Qin N;Giach? V;Bergamini C;Parenti G;Valeri A;Ercolino T;Eisenhofer G;Mannelli M (2014). Pitfalls in Genetic Analysis of Pheochromocytomas/Paragangliomas-Case Report.. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 99, pp. 2321-2326, ISSN:0021-972X DOI Accesso ONLINE all'editore

G. D. Dalmazi;C. Kisker;D. Calebiro;M. Mannelli;L. Canu;G. Arnaldi;M. Quinkler;N. Rayes;A. Tabarin;M. L. Jullié;F. Mantero;B. Rubin;J. Waldmann;D. K. Bartsch;R. Pasquali;M. Lohse;B. Allolio;M. Fassnacht;F. Beuschlein;M. Reincke (2014). Novel Somatic Mutations in the Catalytic Subunit of the Protein Kinase A as a Cause of Adrenal Cushing's Syndrome: A European Multicentric Study.. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 99, pp. E2093-E2100, ISSN:0021-972X DOI Accesso ONLINE all'editore

F. Castinetti;X. Qi;M. K. Walz;A. L. Maia;G. Sansó;M. Peczkowska;K. Hasse-Lazar;T. P. Links;S. Dvorakova;R. A. Toledo;C. Mian;M. J. Bugalho;N. Wohllk;O. Kollyukh;L. Canu;P. Loli;S. R. Bergmann;J. B. Costa;O. Makay;A. Patocs;M. Pfeifer;N. S. Shah;T. Cuny;M. Brauckhoff;B. Bausch;E. v. Dobschuetz;C. Letizia;M. Barczynski;M. K. Alevizaki;M. Czetwertynska;M. U. Ugurlu;G. Valk;J. T. M;P. Sartorato;D. R. Siqueira;M. Barontini;M. Szperl;B. Jarzab;H. H. G;T. Zelinka;P. Vlcek;S. P. A;F. L. Coutinho;M. Mannelli;M. Recasens;L. Demarquet;L. Petramala;S. Yaremchuk;D. Zabolotnyi;F. Schiavi;G. Opocher;K. Racz;A. Januszewicz;G. Weryha;J. Henry;T. Brue;B. Conte-Devolx;C. Eng;H. P. H (2014). Outcomes of adrenal-sparing surgery or total adrenalectomy in phaeochromocytoma associated with multiple endocrine neoplasia type 2: an international retrospective population-based study.. THE LANCET ONCOLOGY, vol. 15, pp. 648-655, ISSN:1470-2045 DOI Accesso ONLINE all'editore

Leone, Alessandra; Pisaneschi, Silvia; Montereggi, Francesco; Canu, Letizia; Corsini, Elisa; Mannelli, Massimo; Montereggi, Alessio (2013). [Arterial hypertension and RU-486: a complex case of secondary hypertension]. GIORNALE ITALIANO DI CARDIOLOGIA, vol. 14, pp. 477-480, ISSN:1827-6806 DOI

Pinzani P; Scatena C; Salvianti F; Corsini E; Canu L; Poli G; Paglierani M; Piccini V; Pazzagli M; Nesi G; Mannelli M; Luconi M. (2013). DETECTION OF CIRCULATING TUMOR CELLS IN PATIENTS WITH ADRENOCORTICAL CARCINOMA: A MONOCENTRIC PRELIMINARY STUDY.. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 98, pp. 3731-3738, ISSN:0021-972X DOI

Giada Poli; Daniele Guasti; Elena Rapizzi; Rossella Fucci; Letizia Canu; Alessandra Bandinelli; Nicoletta Cini; Daniele Bani; Massimo Mannelli; Michaela Luconi (2013). Morphofunctional effects of mitotane on mitochondria in human adrenocortical cancer cells.. ENDOCRINE-RELATED CANCER, vol. 20, pp. 537-550, ISSN:1351-0088 DOI

Rapizzi E; Ercolino T; Canu L; Giachè V; Francalanci M; Pratesi C; Valeri A; Mannelli M (2012). Mitochondrial function and content in Pheochromocytoma/paraganglioma of succinate dehydrogenase mutation carriers. ENDOCRINE-RELATED CANCER, vol. 19, pp. 261-269, ISSN:1351-0088

M. Mannelli; G. Cantini; G. Poli; M. Mangoni; G. Nesi; L. Canu; E. Rapizzi; E. Borgogni; T. Ercolino; V. Piccini; M. Luconi (2010). The role of PPAR-γ system in normal and tumoral corticotroph pituitary and adrenal cells.. NEUROENDOCRINOLOGY, vol. 1 suppl, pp. 23-27, ISSN:0028-3835 DOI

Letizia CANU

Curriculum

Letizia Canu, MD, PhD

Born in Prato (Italy), February 8, 1982

Nationality: Italian

Business address: Dept. Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Pieraccini 6, 50139 Florence – Italy

PROFESSIONAL INFORMATION

Letizia Canu is an MD, Endocrinologist, PhD in Endocrinology & Metabolism. Since 2009, she has been working in the clinical and biology of endocrine tumors, with particular focus on adrenocortical carcinoma and Pheochromocytoma/paraganglioma in collaboration with Prof. M. Mannelli.

EDUCATION

2009 Degree in Medicine and Surgery at University of Florence: 108/110. Experimental thesis “Rosiglitazone Anti-proliferative effects in adrenocortical carcinoma: in vitro and in vivo results”

2016 Specialization in Endocrinology University of Florence: 70/70 cum laude. Experimental thesis “Therapies in metastatic pheochromocytoma/paraganglioma: an unsolved problem”.

2019 PhD in Biomedical Sciences. PhD thesis: “Pheochromocytoma/paraganglioma: radiological aspects and association with second malignant tumors ".”.

CURRENT POSITION – ACADEMIC CAREER

2016-2021 Clinical researcher fellow in Endocrinology with medical assistance at Endocrinology Unit, University Hospital of Florence

2016-2019 PhD in Endocrinological, molecular and regenerative biotechnologies at Dept. Clinical Physiopathology, University of Florence.

From September 2021 Clinical researcher in Endocrinology with medical assistance at Endocrinology Unit, University Hospital of Florence

SCIENTIFIC METRICS

N=70 papers in peer-review International journals (IF: 347.684; mean IF: 5.893)

N=9 paper in national journal, n=4 book chapter

N>100 abstracts at National and International Meetings

Scopus: H-index = 24; Citations = 1714

MEMBERSHIP

European network for the study of Adrenal Tumor (ENS@T); Italian Society of Endocrinology (SIE); European Society of Endocrinology (ESE); Association of Italian Endocrinologist (AME); Member of Scientific Commission of Club Endocrinologia Giovane in Italia (EnGioI) from 26/09/2015 to 31/05/2019; AME GAME referent for the center of Italy from 15/02/2021 at present; Member of the editorial board of journal L’Endocrinologo from October 2023; Secretary of the SIE Adrenal Club from October 2023

EDITORIAL ACTIVITY

2018 - 2022 Editorial Board of Journal of Endocrinological Investigation (JEI)

2021 -2022 Review Editor for Frontiers in Endocrinology

Reviewer for the following scientific journals (Cancers, Current Trends in Internal Medicine, Endocrine, Endocrine Connection, European Journal of Endocrinology, Frontiers in Endocrinology, Genetics in Medicine, Journal of Current Trends in Internal Medicine, Journal of Clinical Endocrinology & Metabolism, Journal of Endocrinological Investigation, Journal of Medical Genetics, Journal of Surgical, Endocrinology, OncoTargets and Therapy)

TEACHING ACTIVITY

2016-present Tutoring activity of n>10 undergraduates in Medicine and Surgery

Supervisor and mentor of thesis (n13)

Teaching activity in School in Endocrinology

Tutoring activity in Degree in Medicine and Surgery

SELECTED PUBLICATIONS (2010-2023)

Canu L, …, Mannelli M. Pitfalls in Genetic Analysis of Pheochromocytomas/Paragangliomas: Case Report. J Clin Endocrinol Metab. 2014;99(7):2321-6. doi: 10.1210/jc.2013-4453. IF=5.399
Papathomas TG, …, Canu L, …, de Krijger RR. SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T). Mod Pathol. 2015;28(6):807-21. doi: 10.1038/modpathol.2015.41. IF=5.988
Salvianti F*, Canu L*, …, Pinzani P and Luconi M. New insights in the clinical and translational relevance of miR483-5p in adrenocortical cancer. Oncotarget. 2017;8(39):65525-65533. doi: 10.18632/oncotarget.19118. IF=5.168. *These authors have equally contributed to the work
Canu L, …, Timmers HJLM. CT characteristics of pheochromocytoma - Relevance for the evaluation of adrenal incidentaloma. J Clin Endocrinol Metab. 2019;104(2):312-318. doi: 10.1210/jc.2018-01532. IF=5.399
Castinetti F, …, Canu L, …, Baudin E. Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study. Lancet Diabetes Endocrinol. 2019;7(3):213-220. doi: 10.1016/S2213-8587(18)30336-X. IF=25.34
Hescot S, …, Canu L, …, Baudin E; European Network for the Study of Adrenal Tumors (ENS@T). Prognosis of Malignant Pheochromocytoma and Paraganglioma (MAPP-Prono Study): A European Network for the Study of Adrenal Tumors Retrospective Study. J Clin Endocrinol Metab. 2019;104(6):2367-2374. doi: 10.1210/jc.2018-01968. IF= 5.399
Rao D, …, Canu L, …, Timmers HJLM. Impact of 123 I_MIBG scintigraphy on clinical decision making in pheochromocytoma and paraganglioma. J Clin Endocrinol Metab. 2019;jc.2018-02355. doi: 10.1210/jc.2018-02355. IF= 5.399
Calsina B, …, Canu L, …, Robledo M. Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma. Theranostics 2019;9(17):4946-4958. doi: 10.7150/thno.35458. IF=8.579
Altieri B, …, Canu L, …, Ronchi CL. Effects of Germline CYP2W1*6 and CYP2B6*6 Single Nucleotide Polymorphisms on Mitotane Treatment in Adrenocortical Carcinoma: A Multicenter ENSAT Study. Cancers (Basel). 2020;12(2):359. doi: 10.3390/cancers12020359. IF=6.126
Doghman-Bouguerra M, …, Canu L, …, Lalli E. Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC. Cancers (Basel). 2020;12(3):689. doi: 10.3390/cancers12030689. IF= 6.126
De Filpo G, …, Canu L. Germline Mutation in KIF1Bβ Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma. Int J Endocrinol. 2020;3671396. doi: 10.1155/2020/3671396. IF=2.299
De Filpo G, …, Canu L. Management and outcome of metastatic pheochromocytomas/paragangliomas: an overview. J Endocrinol Invest. 2020. doi: 10.1007/s40618-020-01344-z. IF=3.397
Bancos I, …, Canu L, …, Arlt W; ENSAT EURINE-ACT Investigators. Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study. Lancet Diabetes Endocrinol. 2020;8(9):773-781.doi: 10.1016/S2213-8587(20)30218-7. IF=25.340
Cantini G, Canu L, …, Luconi M. Prognostic and monitoring value of circulating tumour cells in adrenocortical carcinoma: a preliminary monocentric study. Cancers 2020, 12(11):E3176. doi: 10.3390/cancers12113176. IF=6.126
Crona J, …, Canu L, …, Beuschlein F. ENSAT Registry-Based Randomized Clinical Trials for Adrenocortical Carcinoma. Eur J Endocrinol. 2020:EJE-20-0800.R1. doi: 10.1530/EJE-20-0800. IF=5.308
De Filpo G, …, Canu L. Adrenocortical carcinoma: current treatment options. Curr Opin Oncol. 2021;33(1):16-22. doi: 10.1097/CCO.0000000000000695. IF=3.370
Murakami M, …, Canu L, …, Beuschlein F. Mass Spectrometry Imaging Identifies Metabolic Patterns Associated with Malignant Potential in Pheochromocytoma and Paraganglioma. Eur J Endocrinol. 2021:EJE-20-1407.R1. doi: 10.1530/EJE-20-1407. IF= 5.308
Velema MS, Canu L, …, Deinum J; SPARTACUS Investigators. Volumetric evaluation of CT images of adrenal glands in primary aldosteronism. J Endocrinol Invest. 2021. doi: 10.1007/s40618-021-01540-5. IF= 3.397
Basile V, …, Canu L, …, Terzolo M. What Is the Optimal Duration of Adjuvant Mitotane Therapy in Adrenocortical Carcinoma? An Unanswered Question. J Pers Med. 2021;11(4):269. doi: 10.3390/jpm11040269. IF= 4.433
Cantini G, …, Canu L, …, Luconi M. Circulating fascin 1 as a promising prognostic marker in adrenocortical cancer. Front Endocrinol (Lausanne). 2021;12:698862. doi: 10.3389/fendo.2021.698862. IF=5.468
De Filpo G, …, Canu L. Management and outcome of metastatic pheochromocytomas/paragangliomas: a monocentric experience. J Endocrinol Invest. 2021. doi: 10.1007/s40618-021-01629-x. IF=3.16
Monteagudo M, …, Canu L, …, Robledo M. Analysis of telomere maintenance related genes reveals nop10 as a new metastatic-risk marker in PPGL. Cancers (Basel). 2021 Sep 23;13(19):4758. doi: 10.3390/cancers13194758. IF= 6.639
Cantini G, …, Canu L, …, Maggi M and Luconi M. Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression. J Pers Med. 2021 Oct 27;11(11):1097. doi: 10.3390/jpm11111097. IF= 4.453
Elhassan YS, …, Canu L, …, Ronchi CL. S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study. Eur J Endocrinol. 2021 Nov 30;186(1):25-36. doi: 10.1530/EJE-21-0510. IF=6.341
Canu L, …, Reimondo G. A Multicenter Epidemiological Study on Second Malignancy in Non-Syndromic Pheochromocytoma/Paraganglioma Patients in Italy. Cancers (Basel). 2021 Nov 20;13(22):5831. doi: 10.3390/cancers13225831. IF=6.639
Prete A, …, Canul L, …, Arlt W; ENSAT EURINE-ACT Investigators*; ENSAT EURINE-ACT Investigators. Cardiometabolic Disease Burden and Steroid Excretion in Benign Adrenal Tumors: A Cross-Sectional Multicenter Study. Ann Intern Med 2022;175(3):325-334. doi: 10.7326/M21-1737. IF= 25.391
Canu L, …, Peri A. Case Report: Adrenocortical Oncocytoma in a Patient with a Previous Contralateral Adrenalectomy for a Cortisol-Secreting Adenoma. Front Surg. 2022 19;9:897967. doi: 10.3389/fsurg.2022.897967. IF= 2.568
Provenzano A, …, Canu L. Novel Germline PHD2 Variant in a Metastatic Pheochromocytoma and Chronic Myeloid Leukemia, but in the Absence of Polycythemia. Medicina (Kaunas). 202217;58(8):1113. doi: 10.3390/medicina58081113. IF= 2.985
Fei L, … Canu L, … Luconi M. Carbonic anhydrases III and IX are new players in the crosstalk between adrenocortical carcinoma and its altered adipose microenvironment. J Endocrinol Invest. 2023. doi: 10.1007/s40618-023-02008-4. IF= 4.256
Mellid S, … Canu L, … Cascón A. Co-occurrence of mutations in NF1 and other susceptibility genes in pheochromocytoma and paraganglioma. Front Endocrinol (Lausanne). 2023;13:1070074. doi: 10.3389/fendo.2022.1070074. IF= 6.055
Luconi M, … Canu L, … Nesi G. Prognostic Value of Microscopic Tumor Necrosis in Adrenal Cortical Carcinoma. Endocr Pathol. 2023. doi: 10.1007/s12022-023-09760-6. IF=3.943
Puglisi S, … Canu L, … Terzolo M. New findings on presentation and outcome of patients with adrenocortical cancer: results from a national cohort study. J Clin Endocrinol Metab. 2023:dgad199. doi: 10.1210/clinem/dgad199. IF=6.134
Martinelli S, … Canu L, … Rapizzi E. Tumour microenvironment in pheochromocytoma and paraganglioma. Front Endocrinol (Lausanne). 2023;14:1137456. doi: 10.3389/fendo.2023.1137456. IF= 6.055
De Filpo G, … Canu L. Hemodynamic parameters in patients undergoing surgery for pheochromocytoma/paraganglioma: a retrospective study. World J Surg Onco. 2023;21(1):192. doi: 10.1186/s12957-023-03072-z. IF= 2.754
Amore F, …, Canu L, Rapizzi E. The aggressiveness of SDHB deficient chromaffin cells is reduced when their bioelectrical properties are restored by glibenclamide. Endocr Relat Cancer. 2023 Jul 1:ERC-23-0167. doi: 10.1530/ERC-23-0167. IF= 3.9
Amore F, …Canu L, …, Rapizzi E. The aggressiveness of succinate dehydrogenase subunit B-deficient chromaffin cells is reduced when their bioelectrical properties are restored by glibenclamide. Endocr Relat Cancer. 2023;30(10):e230167. doi: 10.1530/ERC-23-0167. IF= 3.9

Letizia CANU

Letizia CANU

Letizia CANU

Letizia CANU

Insegnamenti relativi all'Anno Accademico 2023-2024 2022-2023 2021-2022 2020-2021

Letizia CANU

Insegnamenti relativi all'Anno Accademico