Robbins & Cotran. Pathologic basis of dieseases Le basi patologiche delle malattie (Elsevier); Majno&Joris. Cells, tissues and diseases.; Spector&Axford.
Modalità di verifica apprendimento
Oral examination. Written examination (true/false and/or multiple choice test upon request for Erasmus students)
Programma del corso
- Health and disease. Classification of causes of disease. Etiology, pathogen and pathogenesis. Homeostasis. Denomination of biomedical disciplines dealing with etio-pathogenesis, diagnosis, clinics and therapy.
CELL INJURY AND DEATH
- Elementary pathological processes. Cell injury, death (apoptosis, necrosis) and adaptation.
INFLAMMATION AND TISSUE REPAIR
- Inflammation: general concepts. Toxicity and persistence within tissue of pathogen and their relationship to the type of inflammatory response. General characters of acute inflammation.
- Pathophysiology of microcirculation.
- Microvascular changes in acute inflammation. Inflammatory oedema.
- Mediators of acute inflammation. Cytokines.
- Cells of acute inflammation; recruitment and action.
- Abscess and "chronic" abscess.
- Chronicized/chronic diffuse (secondary or primary, "aspecific") inflammation and chronic granulomatous (primary, "specific") inflammation.
- Mononuclear phagocyte system. Properties and functions of macrophages. Macrophage activation.
- Tissue repair; healing.
- Systemic effects of inflammation.
- Pathophysiology of thermoregulation.
- Hyperthermia and fever.
- Regeneration and repair. General concepts of clonogenic, stem, progenitor, precursor, differentiated and mature cell.
HEMODYNAMIC CHANGES, THROMBOSIS AND SHOCK
- Hemostasis: platelet aggregation, plasma clotting and fibrinolisis.
-Thrombosis, embolia, hypoxias, ischemia, shock, atherosclerosis.
- General aspects of tumor growth. Etiology and epidemiology of neoplasias. Benign and malignant neoplasias. General denomination of neoplasias.
Natural history of neoplasias: initiation, promotion and progression. Carcinomas in situ, local invasiveness and metastasis.
Molecular bases of neoplasias.