ITA | ENG
B016925 - ANALYSIS OF PHARMACEUTICALS
Main information
Learning Objectives
Course Content
Prerequisites
Teaching Methods
Type of Assessment
Course program
Suggested readings
Further information
Academic Year 2017-18
Course year
Third year - First Semester
Belonging Department
Experimantal and Clinical Medicine
Course Type
Single education field course
Scientific Area
CHIM/08 - PHARMACEUTICAL CHEMISTRY
Credits
6
Teaching Hours
60
Teaching Term
02/10/2017 ⇒ 30/04/2019
Attendance required
No
Type of Evaluation
Final Grade
Course Content
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Course program
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Lectureship
Learning Objectives
The course aims to provide the theoretical and practical basis for the purification and separation of active principles and the control of their quality.
Through lab exercises, the course intends to prepare students to choose and apply appropriate analytical methods in drug analysis.
Through lab exercises, the course intends to prepare students to choose and apply appropriate analytical methods in drug analysis.
Course Content (Search our library's catalogue)
Biotechnology Disciplines with Specific Chemical and Pharmaceutical Purposes (SSD CHIM / 08)
Prerequisites
Good knowledge of inorganic and organic chemistry.
Teaching Methods
Frontal Lectures (3CFU), Practical Laboratory Exercises (3CFU)
Theoretical lesson attendance is highly recommended while the frequency of practical exercises is mandatory
Theoretical lesson attendance is highly recommended while the frequency of practical exercises is mandatory
Type of Assessment
Oral Exam. The final evaluation also takes into account the results achieved in laboratory exercises.
Course program
Fronctal lectures: Purification and separation of active ingredients: crystallization, sublimation, distillation, extraction methodologies (solid-liquid extraction, liquid-liquid extraction), solid phase extraction (SPE, SPME).
Chromatography: classification of the various techniques, separation theory, efficiency of a chromatographic system. Thin layer chromatography. Gaschromatography and HPLC: technical and application aspects.
Application of some spectroscopic techniques in the analysis: UV, IR, 1HNMR
Introduction to mass spectrometry.
EXERCISES: Crystallization of an unknown sample; extraction of caffeine from coca cola by liquid-liquid extraction and by SPE solid phase extraction; separation of a binary mixture; analgesic drugs analysis by TLC; recognition of mixture components by TLC; water sample analysis by ion exchange chromatography
Chromatography: classification of the various techniques, separation theory, efficiency of a chromatographic system. Thin layer chromatography. Gaschromatography and HPLC: technical and application aspects.
Application of some spectroscopic techniques in the analysis: UV, IR, 1HNMR
Introduction to mass spectrometry.
EXERCISES: Crystallization of an unknown sample; extraction of caffeine from coca cola by liquid-liquid extraction and by SPE solid phase extraction; separation of a binary mixture; analgesic drugs analysis by TLC; recognition of mixture components by TLC; water sample analysis by ion exchange chromatography
Suggested readings
Material provided by the teacher at the beginning of the course.Analisi chimico farmaceutica. F. Savelli, O. Bruno. Ed. PICCIN.
Elementi di analisi chimica strumentale. R. Cozzi, P. Protti, T. Ruaro. Ed. Zanichelli
Elementi di analisi chimica strumentale. R. Cozzi, P. Protti, T. Ruaro. Ed. Zanichelli
Further information
Student reception: daily by appointment via e-mail.