PowerPoint presented in classroom and scientific articles delivered during lesson
Learning Objectives
To know the cytogenetic and molecular causes of infertility and the ability to apply the methods of analysis
Teaching Methods
Lectures and lab practice exercises
Type of Assessment
Oral examination with presentation of a topic discussed during the course
Course program
GENETIC CAUSES OF Male and Female INFERTILITYCAUSE MALE INFERTILITYChromosomal abnormalities (autosomal and sex chromosomes). Genetic disorders associated with abnormalities in secretion or action of gonadotropins. Mutations of some genes involved in spermatogenesisChromosomal alterations in male infertility:Alteration of the X chromosomeAlteration of the Y chromosomeDeletions-duplicationsTranslocations of genes from the X chromosome to autosomes or to the Y chromosomeTranslocations, Deletions and mutations of the SRY gene.Chromosomal rearrangements of autosomes responsible for infertilityRobertsonian translocationsPeri-and Paracentric inversionsMarkers and infertilityGenes and male infertility: e.g AR, SRD5A2CNV and Spermatogenic FailureSynaptonemal ComplexCAUSES OF FEMALE STERILITYChromosomal alterations: Numerical / StructuralX / Autosome translocationsPOF in Xq26-q27e in Xq13-q21Other genes responsible for POFExpansions of the CGG repeat to the 5'UTR of the FMR geneAdrenogenital syndrome